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Leonard I Wiebe Selected Research

Radiotherapy

1/2019Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia.
1/2016Synthesis and Biological Evaluation of Iodoglucoazomycin (I-GAZ), an Azomycin-Glucose Adduct with Putative Applications in Diagnostic Imaging and Radiotherapy of Hypoxic Tumors.
10/2012In vitro and in vivo evaluation of [(18)F]F-GAZ, a novel oxygen-mimetic azomycin-glucose conjugate, for imaging hypoxic tumor.

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Leonard I Wiebe Research Topics

Disease

21Neoplasms (Cancer)
03/2019 - 03/2003
16Hypoxia (Hypoxemia)
08/2022 - 11/2002
3Herpes Simplex
01/2012 - 07/2004
2Osteosarcoma (Osteogenic Sarcoma)
06/2007 - 07/2005
1CHARGE Syndrome
02/2024
1Renal Cell Carcinoma (Grawitz Tumor)
12/2014
1Squamous Cell Carcinoma of Head and Neck
10/2009
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
10/2009
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2009
1Glioma (Gliomas)
10/2009
1Lymphoma (Lymphomas)
10/2009
1Hepatocellular Carcinoma (Hepatoma)
10/2008
1Chickenpox
06/2007
1Herpes Zoster
06/2007
1Carcinosarcoma
04/2003

Drug/Important Bio-Agent (IBA)

6NucleosidesIBA
02/2024 - 07/2005
6azomycinIBA
01/2019 - 11/2002
6fluoroazomycin arabinosideIBA
01/2018 - 01/2005
6NitroimidazolesIBA
01/2017 - 01/2005
5Thymidine KinaseIBA
06/2007 - 03/2003
4iodoazomycin arabinosideIBA
08/2022 - 08/2005
4RadiopharmaceuticalsIBA
01/2019 - 10/2009
4Glucose (Dextrose)FDA LinkGeneric
01/2018 - 07/2012
2Antiviral Agents (Antivirals)IBA
02/2024 - 10/2008
2Tirapazamine (SR 4233)IBA
01/2020 - 01/2019
25-fluoro-2'-deoxyuridineIBA
10/2013 - 03/2003
2ProdrugsIBA
10/2013 - 08/2005
2Oxygen (Dioxygen)IBA
10/2012 - 01/2005
2ThymidineIBA
01/2012 - 05/2009
2DeoxyuridineIBA
06/2007 - 07/2004
25- (2- iodovinyl)- 1- (2'- fluoro- 2'- deoxyuridine)IBA
07/2005 - 07/2004
2fluoromisonidazoleIBA
01/2005 - 04/2003
2EnzymesIBA
03/2004 - 03/2003
2Therapeutic UsesIBA
03/2004 - 03/2003
2Idoxuridine (Stoxil)FDA LinkGeneric
12/2003 - 03/2003
1NucleotidesIBA
02/2024
1IsotopesIBA
08/2022
1Radiation-Sensitizing AgentsIBA
03/2019
1OxidesIBA
01/2019
1IodoglucoazomycinIBA
01/2016
1pimonidazoleIBA
12/2014
1Tyrosine Kinase InhibitorsIBA
12/2014
1Sunitinib (Sutent)FDA Link
12/2014
1von Willebrand FactorIBA
12/2014
1Floxuridine (FUdR)FDA LinkGeneric
10/2013
1Tretinoin (Retinoic Acid)FDA LinkGeneric
10/2013
16- O- (9- (2- nitro- 1H- imidazolyl)- 8- fluoropropyl)glucopyranoseIBA
10/2012
1Carrier Proteins (Binding Protein)IBA
07/2012
1Phosphotransferases (Kinase)IBA
01/2012
1O-(18F)fluoromethyl-L-tyrosineIBA
01/2012
1Nucleoside Transport Proteins (Nucleoside Transporter)IBA
01/2012
1Ribose (D-Ribose)IBA
03/2010
1iodobenzeneIBA
05/2009
1Asialoglycoprotein ReceptorIBA
10/2008
1Cytostatic AgentsIBA
06/2007
1Fluorouracil (Carac)FDA LinkGeneric
01/2007
1Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2005
1AntimetabolitesIBA
08/2005
1DNA (Deoxyribonucleic Acid)IBA
08/2005
13'- O- (3- benzenesulfonylfuroxan- 4- yl)- 5- iodo- 2'- deoxyuridineIBA
08/2005
1Nucleic AcidsIBA
08/2005
1Proteins (Proteins, Gene)FDA Link
08/2005
1pyrimidineIBA
07/2005
11- beta- D- arabinofuranosyl- 2- nitroimidazoleIBA
01/2005
1carbogenIBA
01/2005
1fialuridineIBA
07/2004
1Pyrimidine NucleosidesIBA
07/2004
1Phosphates (Orthophosphate)IBA
12/2003
1Isosorbide Dinitrate (Isordil)FDA LinkGeneric
03/2003
1Cysteine (L-Cysteine)FDA Link
03/2003
1GlucuronidesIBA
11/2002
1Technetium (Technetium 99m)IBA
11/2002

Therapy/Procedure

4Therapeutics
12/2014 - 08/2005
3Radiotherapy
01/2019 - 10/2012
3Drug Therapy (Chemotherapy)
12/2014 - 01/2007
2Intravenous Injections
08/2005 - 07/2005
1Precision Medicine
01/2019
1Electrodes (Electrode)
01/2005